This talk aims to accessibly introduce a new theory of network architecture relevant to biology, medicine and technology (particularly SDN/NFV and cyberphysical systems), initially minimizing math details. Key ideas are motivated by familiar examples from neuroscience, including live demos using audience brains, and further illustrated with examples from technology and biology. The status of the necessary math will be sketched in as much detail as time permits. Background material is in online videos (accessible from website above) and a recent blog post: rigorandrelevance.wordpress.com/author/doyleatcaltech. My research is aimed at developing a more “unified” theory for complex networks motivated by and drawing lessons from neuroscience, cell biology, medical physiology, technology (internet, smartgrid, sustainable infrastructure), and multiscale physics ,,. This theory involves several elements: hard limits, tradeoffs, and constraints on achievable robust, efficient performance ( “laws”), the organizing principles that succeed or fail in achieving them (“architectures” and protocols), the resulting high variability data and “robust yet fragile” behavior observed in real systems and case studies (behavior, data, statistics), the processes by which systems adapt and evolve (variation, selection, design), and their unavoidable fragilities (hijacking, parasites, predation, zombies). We will leverage a series of case studies with live demos from neuroscience, particularly vision and sensorimotor control, plus some hopefully familiar and simple insights from medicine, cell biology and modern computer and networking technology. Zombies emerge throughout as a ubiquitous, strangely popular, and annoying system fragility, particularly in the form of zombie science. In addition to the above mentioned blog and videos, papers  and  (and references therein) are the most accessible and broad introduction while the other papers give more domain specific details. For math details the best place to start is Nikolai Matni’s website (cds.caltech.edu/~nmatni/).
Selected recent references:
 Alderson DL, Doyle JC (2010) Contrasting views of complexity and their implications for network-centric infrastructures. IEEE Trans Systems Man Cybernetics—Part A: Syst Humans 40:839-852.
 Sandberg H, Delvenne JC, Doyle JC. On Lossless Approximations, the Fluctuation-Dissipation Theorem, and Limitations of Measurements, IEEE Trans Auto Control, Feb 2011
 Chandra F, Buzi G, Doyle JC (2011) Glycolytic oscillations and limits on robust efficiency. Science, Vol 333, pp 187-192.
 Doyle JC, Csete ME(2011) Architecture, Constraints, and Behavior, P Natl Acad Sci USA, vol. 108, Sup 3 15624-15630
 Gayme DF, McKeon BJ, Bamieh B, Papachristodoulou P, Doyle JC (2011) Amplification and Nonlinear Mechanisms in Plane Couette Flow, Physics of Fluids, V23, Issue 6, 065108
 Page, M. T., D. Alderson, and J. Doyle (2011), The magnitude distribution of earthquakes near Southern California faults, J. Geophys. Res., 116, B12309, doi:10.1029/2010JB007933.
 Namas R, Zamora R, An, G, Doyle, J et al, (2012) Sepsis: Something old, something new, and a systems view, Journal Of Critical Care Volume: 27 Issue: 3
 Chen, L; Ho, T; Chiang, M, Low S; Doyle J,(2012) Congestion Control for Multicast Flows With Network Coding, IEEE Trans On Information Theory Volume: 58 Issue: 9 Pages: 5908-5921
 Li, Cruz, Chien, Sojoudi, Recht, Stone, Csete, Bahmiller, Doyle (2014) Robust efficiency
John Doyle is the Jean-Lou Chameau Professor of Control and Dynamical Systems, Electrical Engineer, and BioEngineering at Caltech (BS&MS EE, MIT (1977), PhD, Math, UC Berkeley (1984)). Research is on mathematical foundations for complex networks with applications in biology, technology, medicine, ecology, and neuroscience. Paper prizes include IEEE Baker and Automatic Control Transactions (twice), ACM Sigcomm, AACC American Control Conference. Individual awards include IEEE Power Hickernell, AACC Eckman, UCB Friedman, IEEE Centennial Outstanding Young Engineer, and IEEE Control Systems Field Award. Best known for fabulous friends, colleagues, and students, plus national and world records and championships in various sports. Extremely fragile.