Computational Analysis and Design of DNA Devices

 

Niles Pierce
Assistant Professor

Applied & Computational Mathematics
and Bioengineering
California Institute of Technology
 

Single-stranded DNA is a versatile construction material that can be programmed to self-assemble into nanoscale devices driven by the free energy of base pair formation. This talk will describe our efforts to develop a general computational framework for the analysis and design of DNA systems. Experimental demonstrations will include the locomotion of a synthetic DNA walker and biosensing using the mechanism of hybridization chain reaction.