Steven H. Kleinstein

	Steven H. Kleinstein
Research Staff, PICASso Program Coordinator Department of Computer Science, Princeton University

Please visit my current website at the Department of Pathology, Yale University School of Medicine

	My general research interest is the development of computational methods that leverage mathematical models and numerical simulations in order to improve understanding of experimental data. The immune system has been a particular focus of my work.
	We recently developed the first rigorous method to estimate mutation rates during in vivo immune responses. This method produces a maximum likelihood estimate by comparing genealogical trees generated from experimentally observed DNA sequences with those produced by a stochastic branching process simulation. Using data collected by an experimental collaborator at Yale, I was able show that specific cells in an autoimmune mouse were mutating in an unexpected area of the spleen. This has great implications for understanding the onset of systemic lupus erythematosus and other autoimmune diseases. Previously, I was involved with the immune system simulation IMMSIM. In addition to research, this simulation was used in a freshman seminar on immunology at Princeton.
	As part of the Program for Research on Immune Modeling and Experimentation, I am working to develop mathematical models to elucidate the viral mechanisms of induction and subversion of type 1 interferon responses and maturation of dendritic cells by Category A-C viral pathogens. This is a collaboration between Mount Sinai School of Medicine, Princeton University, Ohio State University, and the BioAnalytics Group LLC.
	I currently run PICASso, a graduate-training program in computational science at Princeton University. This program trains interdisciplinary graduate students in integrative research in the computational pipeline, from applications through models and methods to scalable computing, and visualization.
	Over the years, I've been associated with some great companies including WorldView Software, Cambridge Technology Group, Physiome Sciences, and The BioAnalytics Group. I am currently a member of the Scientific Advisory Board of Immunetrics.
	My wife, Judy Kleinstein, is a board-certified physician practicing internal medicine. My daughter, Allison Charlotte, was born in July, 2003. My son, Zachary Hiram, was born in April, 2005.
	I attended P.S. 188, J.H.S. 172, The Bronx High School of Science, The University of Pennsylvania, and Princeton University (Department of Computer Science). I completed my Ph.D. thesis in June of 2002: Toward Quantitative Models of Germinal Center Dynamics.