Advances in biomedicine and its effective translation from the bench to
the bedside (and back) requires the efficient and secure development and
deployment of cyber-infrastructure (i.e. computing, network and storage
platforms) in conjunction with analytic, and interpretive methods to
optimize the integration and transformation of increasingly voluminous
biomedical data from high-throughput experiments and Internet enabled
medical devices. This includes research on the development of novel
techniques for the integration of biological and clinical data and the
evolution of clinical informatics methodology to encompass biological
observations. The end product is newly found knowledge from these
integrative efforts that can be disseminated to a variety of
stakeholders, including biomedical scientists, clinicians, and patients
targeted towards the goal of of realizing proactive, predictive,
preventive, personalized and participatory health.
In this talk, I will
overview projects I have been involved in at the BIOPOLIS, a
basic/translational research, development and education hub involving a
public/private partnership in Singapore, where the above issues have been
addressed with some success. I will outline our plans at the Cancer
Institute of New Jersey to replicate this success and take it to the next
level by working in partnership with academia and Industry in New Jersey.
To this end, I will address some of the many infrastructure and data
integration/mining challenges that form a barrier to realizing
translational research which I hope will serve to catalyze new
collaborative links with colleagues at Princeton.
Selected publications:
Vedula S.R.K., TS Lim., Kausalya P.J, Hunziker W., G. Rajagopal and Lim C.T, “Biophysical approaches for studying the integrity and function of tight junctions”, Molecular and Cellular Biomechanics, 2, 105-123, 2006.
CM Song, BH Yeo, E. Tantoso, Y. Yang, YP Lim, KB Li and G. Rajagopal, “iHAP * Integrated haplotype analysis pipeline for characterizing the haplotype structures of genes”, BMC Bioinformatics, 7:525, 2006
KH Chiam, C.M. Tan, V. Bhargava, and G. Rajagopal, “Hybrid simulations of stochastic reaction-diffusion processes for modeling intracellular signaling pathways”, Physical Review E 74, 51910, 2006.
