Trading Computation for Experiment: Noninvasive Imaging, Analysis and Application
Jeffrey Saltzman
Sr. Director Applied Computer Sciences and Mathematics, Merck
We describe how various noninvasive imaging methods can be combined with mathematical modeling to yield useful data about disease and its treatment. We give an overview of Positron Emission Tomography (PET) and Magnetic Resonance Imaging (MRI) methods. Once the imaging principles are established we move onto how these methods are used to derive kinetics traces for radio-labeled compounds or answer questions about brain morphology. The success and failures of these approaches lead to some interesting mathematical and computational questions.