In Silico Approaches to Transcriptional Regulation and its Evolution Sridhar Hannenhalli
Transcriptional control is recognized as an important component of the overall regulation of cellular processes. We have been focusing on computational approaches to a variety of problems pertaining to eukaryotic transcriptional regulation, namely, (1) representation and identification of transcription factor binding sites, (2) PolII promoter prediction, (3) Predicting interaction among transcription factors, (4) identifying groups of TFs - Transcriptional modules - that co-regulate a set of transcripts. I will present a brief overview of the computational approaches and challenges as well as a number of applications. I will also present some recent unpublished work pertaining to the evolution of paralogous transcription factors.
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