Analyzing and Interrogating Protein Interaction Maps

Mona Singh

Computer Science Department, Lewis Sigler Institute, Princeton University

High-throughput technologies have determined physical interactions for a significant fraction of proteins in several organisms. Taken together, these linkages form large protein interaction networks. Computational analysis of these networks can help uncover the functions of individual proteins as well their roles within larger pathways. In this talk, I will introduce novel methods for analyzing protein interaction networks and uncovering recurring means with which diverse biological processes are carried out.  Our approach lends insight into the organizational principles of protein networks and can be used to determine functionally cohesive subnetworks and help predict protein function.