Prediction and Analysis of Protein and Domain Interactions

Teresa Przytycka

Computational Biology, NIH

Comprehending the cell functionality requires knowledge about the functionality of individual proteins as well as the interactions among them. In the last few years new high-throughput interaction detection methods generated enormous amounts of interaction information, usually represented in the form of protein-protein interaction network.  In this talk I will address two challenging questions in analyzing protein-protein interaction data.  First, while some proteins form stable complexes, other form transient associations and are part of different complexes at different stages of a cellular process. Deciphering information about temporal relations between interactions presents a formidable challenge.  Furthermore, proteins typically contain two or more domains, and a protein interaction usually involves binding between specific pairs of domains. Identifying such interacting domain pairs is an important step towards understanding the protein-protein interaction network.